Hearing loss can be inherited. Both
dominant and recessive genes exist
which can cause mild to profound
impairment. If a family has a dominant
gene for deafness it will persist
across generations because it will
manifest itself in the offspring even
if it is inherited from only one
parent. If a family had genetic hearing
impairment caused by a recessive gene
it will not always be apparent as it
will have to be passed onto offspring
from both parents. Dominant and
recessive hearing impairment can be
syndromic or nonsyndromic. Recent gene
mapping has identified dozens of
nonsyndromic dominant (DFNA#) and
recessive (DFNB#) forms of deafness.
- The most
common type of congenital hearing
impairment in developed countries
is DFNB1, also known as Connexin 26
deafness or GJB2-related
deafness.
- The most
common dominant syndromic forms of
hearing impairment include Stickler
syndrome and Waardenburg
syndrome.
- The most
common recessive syndromic forms of
hearing impairment are Pendred
syndrome, Large vestibular aqueduct
syndrome and Usher syndrome.